### A functional entropy model for biological sequences

Durston KK, Chiu DKY.

This paper introduces

Durston KK says of this paper:

**A functional entropy model for biological sequences**.*Dynamics Of Continuous Discrete And Impulsive Systems, Series B: Applications & Algorithms*2:722-725*Sp. Iss. Si*2005. [also presented at the*Proc. 4th Intern. Conf. on Engineering Applications and Computational Algorithms*]This paper introduces

**functional entropy**as a measure of entropy that incorporates functional interpretations**corresponding to certain biological functions**. A measure of**change of functional entropy**is defined to measure**entropy change between two functional states**. We show here two biosequence analysis experiments based on**the ankyrin repeat**and**the**. They show how two*Ubx*box gene**related biomolecules with different biological functions**can be**compared and analyzed**. Furthermore, with a given**limit on entropy change**, intermediaries between states can also be estimated and evaluated.Durston KK says of this paper:

"Finding novel proteins is unlikely to occur through a series of functional intermediates, and will therefore degenerate to a random walk."

Note: Thanks to Dr. A. Voie for this excellent reference!

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